Despite the loss, Pochettino praised the fighting spirit of his team, especially after conceding so early.
"With all respect to other players, who have won it [Ballon d'Or], we know there is a player who is different to the others, and that is Leo Messi", Rakitic said post-game.
Messi arrived at Wembley with a reputation as one of the best players to have ever played the game.
Messi was also involved in Barca's opener before taking his Champions League tally to 64 goals from 65 appearances in the group stage, while Jordi Alba recorded a trio of assists.
Ivan Rakitic thumped home Barca's second with a goal of the highest technical order but Spurs rallied in the second half and threatened a comeback through an equally well taken Harry Kane strike. 'I want to congratulate the team, because we were always in the game, always fighting, never giving up. When you start off at that level of game against Barcelona, it makes it so tough'.
But Pochettino rejected the opinion that Messi had nearly single-handedly dismantled his team, adding: "We didn't concede one chance to Messi in the first half".
Former Barca striker Gary Lineker described Messi as the best player in history on social media and Coutinho was quick to agree with that assessment after scoring his first Champions League goal for the club.
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According to Spanish outlet AS, the report said: " Piqué is critical of Messi for not facing up [to the press] when the going gets tough".
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Spurs did manage to carve out a couple chances as the half went on, but the LaLiga outfit did well to preserve their lead as they headed into the break.
'We played with the handicap of conceding after one minute.
'I'm disappointed with the result but the effort was massive. Lucas Moura could have equalised for us. But against a team like Barcelona, this type of game when you play at that level, to give that advantage to a team like Barcelona is so hard to come back from.
Barcelona thrashed PSV 4-0 at the Nou Camp in their opening Champions League game.
His performance was reminiscent of the Champions League final at this same venue in 2011 when Messi, then at the peak of his powers, destroyed Manchester United with a spellbinding performance against Sir Alex Ferguson's team.
"We need to play four games still and we have it in our hands to be in the next stage".
In recent weeks there have been murmurs that Barcelona have been struggling after three games without a win in La Liga. "We're still thinking the same, though, that all is possible".