Germany lost back-to-back games after throwing away a 1-0 lead against the world champions, with an Antoine Griezmann double after half-time enough to see them off.
"This is the difference between a team with a lot of confidence and a team like Germany which lacks some confidence and is maybe not as efficient", France coach Didier Deschamps told reporters.
Kylian Mbappe's electrifying speed was soon on display, but Hugo Lloris initially proved the far busier of the two goalkeepers as Germany sought to end a run of three competitive matches without a goal. "We were unable to put the ball in the goal", said Loew.
Lloris guessed correctly and dived to his left although the Tottenham keeper could only help the ball into the corner of the net.
Serge Gnabry came close to restoring the lead for Low's men 20 minutes before time with a threatening low strike from the left side of the box that was saved by Lloris.
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Griezmann's clincher from 12 yards came with 10 minutes remaining, when Mats Hummels' foot was trodden on by Matuidi as he attempted to make a sliding challenge, and referee Milorad Mazic pointed to the spot on Tuesday. The hosts carried their momentum into the second half and levelled on 62 minutes.
Griezmann equalised with a magnificent glancing header from a Lucas Hernandez cross on the hour, and the Atletico Madrid striker won the game for France with a penalty 10 minutes from time.
"I'm disappointed with the result, although though I must say the defeat is different to Saturday's", said Loew.
The result eliminated Germany from Nations League title contention, and left them needing to beat the Netherlands in their final group match on November 19 if they are to avoid relegation from the top tier.