Hamilton also had a close call in the morning, jinking hard to avoid Pierre Gasly's Toro Rosso and taking the escape road at the final chicane after the Frenchman appeared to back off on the racing line.
The two drivers were summoned to see the stewards to discuss the incident, where officials handed Gasly a reprimand.
"This track is awesome", he whooped over the team radio. "I'm having the best day!" he giggled during Practice Two.
Hamilton's pace continued the impression that Mercedes have made a dramatic step forward in performance following the end of the European season. "It's incredible - they don't make tracks like this anymore".
But Vettel, whose hopes of pipping Hamilton to a fifth world title are quickly evaporating following the Briton's run of five victories in the last six races, refused to hit the panic button.
Hamilton now holds a 50-point lead over Vettel in the championship, and no driver has ever overhauled as big a deficit since the current scoring system began eight years ago.
Hamilton finished the best part of half-a-second faster than anybody else in practice on Friday. It's very marginal being on the limit and it's so quick through that first section, being that you go down into Turn 1, up through the Essess and then you are braking down into Turn 8, it's very cool.
Nana Patekar finally addresses the media in Tanushree Dutta's harassment controversy
Nana Patekar addressed Tanushree Dutta sexual harassment claims on Monday afternoon with a one line comment to the media. Patekar was shooting for the upcoming film Housefull 4 in Jodhpur, and landed in Mumbai on Saturday.
Melania Trump voices admiration of Egyptian civilization
History has shown that a pith helmet was commonly worn by European military officials as they came to Africa to colonize the area. For many, Melania's attempt to tout anti-racism but refusing to confront her overtly racist husband is rather unfortunate.
Darren Bravo, Kieron Pollard Get West Indies T20 Recall for India Series
Surprisingly, Chase and Paul had little difficulty in picking the chinaman, who bowled the first over of the day. Kuldeep Yadav picked 5 wickets for 57 runs in 14 overs, followed by Ravindra Jadeja who picked 3 for 35 runs.
"I've just been giving thanks all day today just because this is what I've always wanted to do", he said.
"But I think overall, it has been OK".
"I think I've said many times that we have a strong vehicle, but I don't think, against the people's opinions, that we had a dominant auto at any point this year", the German said. "Now I just have to stay on it, keep working".
"It's also going to be a lot warmer in the race, so that will be different, but at least we got enough running already in dry conditions, so it doesn't matter if it's wet tomorrow". "If we can grasp pole tomorrow, that is great, but if not we need to be there just right behind". "I wasn't totally satisfied with the feeling in the auto today".
"No interruptions, no issue with the vehicle or anything, so now we have to try to obviously squeeze out everything that is left in the auto for tomorrow".
"In the morning they were quicker through nearly every corner, but they had a softer tyre", he explained.
Fernando Alonso was 17th fastest and team-mate Stoffel Vandoorne slowest of all, a second off the Spaniard.