The London gunners last lost a match in August 2018 against rivals Chelsea.
But Emery freshened up his side with six changes, although one was enforced as Mesut Ozil was sidelined due to a back spasm, and there were no signs of fatigue as they took the lead in the 29th minute.
Fulham, the only top-flight side without a clean sheet this season, levelled 15 minutes later when Monreal needlessly gave the ball away and Andre Schuerrle dinked the ball over Bernd Leno as the goalkeeper rushed out.
Arsenal started the second half on the front foot and after Hector Bellerin had gone close we found the second goal as Lacazette fired home a superb effort from 20 yards in the 48th minute.
Fulham hit back against the run of play in the 44th minute. But they showed the quality, the pace, the strength too'.
Picking a man of the match has been hard, with a number of excellent performances across the pitch for Arsenal at Craven Cottage.
Aside from his goalscoring, the forward's all-round play was a real highlight for the Gunners, who are reaping the rewards of the striker's increasing confidence.
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Twitter reacted to Arsenal's victory and here are some of the best tweet.
"We tried to win the game".
Emery's side turned on the style on the banks of the River Thames, romping to their biggest win of the season as the resurgent Gunners moved into the Premier League's top four.
The Frenchman was nominated for the Premier League player of the month for September and has started October in a similar vein.
Finally he met Pierre-Emerick Aubameyang's low cross with a delicate flick with the inside of his boot to beat Marcus Bettinelli in the Fulham goal and conjure memories of the sort of goals Dutch great Johan Cruyff used to score.
Arsenal return to action after the worldwide break in just over a fortnight when they host Leicester City on October 22.
Aubameyang and Ramsey had both been left on the bench, but Emery introduced them for the final half hour in a bid to kill off Fulham.