New Orleans defeated the Washington Redskins 43-19.
It also took Brees fewer games than Manning to pass for 71,740 yards - Brees achieved the feat in 253 games compared to Manning's 266.
The touchdown pass gave the Saints a 26-6 lead as they sought to move into first place in the NFC South division. How about that? Hey, I love you guys so much. He has 499 career touchdown passes.
"Also, let this serve as the congratulations for the touchdown record, because as you can see, I am very busy".
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"I don't have time to keep doing these videos for you". "All your hard work and dedication has paid off".
"You and I have come a long way since this picture".
Over his 12 full seasons with the Saints, Brees quarterbacked the team to its first Super Bowl title and another appearance in the NFC championship game, and he has led the National Football League in passing yardage seven times, including from 2014 to 2016.
The game continued after with the Saints unsuccessfully attempted a two-point conversion - with Brees notably split out as a receiver, at least in theory, while backup quarterback Taysom Hill took the snap and tried to run into the end zone.
The game featured other touches meant to honour Brees.
Brees also was the final Saints player to run onto the field during pre-game introductions as fans belted out elongated howls of "Dreeeeeeew".