The building, constructed on high ground and with a massive 750-kilowatt diesel generator that can provide power for at least three days, is stuffed with food, water, medications and medical supplies, Goins said.
The National Hurricane Center says it's now expected to hit Wilmington and then veer west, taking it south of Charlotte.
"Today is the time to get your preparedness actions complete", he said.
"Whether it's a breathing machine or medicine that's going through their veins ― those types of medicines and life-supporting measures would make them too unstable to move", said Dede Carey, clinical manager of the cardiovascular intensive care unit at Roper.
As of 11 p.m., the storm was centered 280 miles east southeast of Wilmington, North Carolina, and was moving northwest at 17 mph.
More than 1 million people have been ordered to evacuate the coastlines of the Carolinas and Virginia.
Large and unsafe, Hurricane Florence is drawing closer to the coast of the Carolinas, where it threatens to become the most intense storm to strike the region in at least 25 years, since Hugo. Residents in coastal areas should follow evacuation orders from local officials because of the potential for life-threatening storm surge flooding.
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The hurricane is expected to weaken into a tropical depression as it continues westward into SC and Georgia.
Many nursing-home and elder-care institutions throughout the Carolinas closed and evacuated their residents in advance of Florence, anxious about a repeat of last year's deaths of elderly residents after Hurricane Irma struck Florida.
"All my staff are gone", Thompson said.
"What can you do?" she asked.
"The preparation has been done and now it's up to mother nature as to what happens", he said. When he packed up the 20-pound brown paper bag he left town with, he says, he remembered to bring his nebulizer, toiletries, and a change of clothes, but left behind his blood pressure medication. "If it wasn't for them, I wouldn't have minded staying here".
Duke Energy has around 4 million customers in North and SC, and says it could take several weeks to restore the electricity.
Florence is being trailed in the Atlantic by two other storms - Hurricane Helene and Tropical Storm Isaac.
Helene was weakening, however, and posed no danger to land, the NHC said, while Isaac could bring heavy rain to Martinique, Dominica and Guadeloupe.