"We believe it is utterly inadmissible to draw parallels between the authorities of Russia and the incident in Salisbury", he said adding that "accusing Russia of lies after an interview with two Russian nationals is absurd as well since they are ordinary citizens and have nothing to do with the government".
The interview prompted scorn and mockery in Britain.
The naming of suspected GRU agents Alexander Petrov and Ruslan Boshirov as the Salisbury Novichok assassins has reportedly left Russian intelligence chiefs reeling.
Boshirov replied: "Let's not pry into our private lives".
The cathedral became a popular search on the website after it emerged Alexander Petrov and Ruslan Boshirov, the two men Britain has accused of being Russian assassins, allegedly stopped by to see the historical structure and its 123 metre spire.
The newspaper Vedomosti headlined its report on the broadcast: "An interview, but no information".
She also said they had agreed to send photos taken during their visit to Salisbury but their phone no longer appeared to be in use.
Some social media users were quick to point out that numerous facts cited are also in the first paragraphs of Salisbury Cathedral's Wikipedia entry.
"From Heathrow Airport, they returned to Moscow on Aeroflot flight SU2585, departing at 10.30pm on Sunday, 4 March".
"The Spy Who Went Home Because It Was Cold", quipped Twitter user Ben Stanley.
"I think they're telling the truth..."
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The two men, both wearing blue jumpers, said they were civilians in the sports nutrition business.
But instead of heading in the direction of the cathedral, they went the other way and were captured 10 minutes later near a Shell petrol garage on Wilton Road.
They reeled off facts about the "beautiful city" and the friends' recommendations that had inspired them to visit.
The two accused men spoke on camera for almost 30 minutes, rarely smiling as they discussed their actions with RT's Editor-in-Chief Margarita Simonyan.
But Maria Kazimi, a student in Moscow, rejected the idea the pair were either a gay couple or spies on a killing mission.
Their detailed description of Salisbury's medieval cathedral and tall spire were part of the latest in a series of zigs, zags and twists from Russian Federation since Britain last week pointed the finger at the pair in the poisoning of ex-spy Sergei Skripal and his daughter, Yulia.
A still image taken from an undated video shows Sergei Skripal, a former colonel of Russia's GRU military intelligence service, being detained by secret service officers in an unknown location.
Downing Street on Thursday called the RT interview "an insult to the public's intelligence".
The two men had some physical similarities to the men shown in British police images. And a correspondent speaking after the interview said that it gave "their version of the events" but "leaves more questions than answers".
They all recovered but a fake perfume bottle containing Novichok was picked up by a local man.
Russia Today attempted to make inferences about their sexuality, asking: "All the footage features you two together".
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