"If our own great grandchildren don't have lives better than ours, something has gone very wrong", Bezos said in a tweet on Thursday.
Bezos asked for suggestions for philanthropic focuses in a tweet a year ago.
Bezos's wealth has allowed him to pay for side ventures, including starting space exploration company Blue Origin and buying the Washington Post newspaper. We reached out to Amazon for more information and were directed to contact four individuals who were "briefed and are willing to talk to media" - the CEOs of Community of Hope, the National Alliance for Ending Homelessness, the Buffett Early Childhood Fund, and Mary's Place (which receives a special mention in Bezos's announcement.) Amazon would not provide comment on the Day 1 Fund or contact information for anyone directly involved in disbursement.
Bezos, and Amazon, have been criticized in Seattle for not doing more to help the needy and have become focal points in the booming region's angry debate about traffic, housing prices and homelessness.
Later, Bezos told a Washington gathering that the $2 billion was only a start and that he would likely expand his philanthropic efforts.
Some analysts have suggested Amazon could face antitrust scrutiny over its growing power in the economy, and President Donald Trump has accused the company of taking advantage of the Postal Service, despite studies suggesting the internet giant's deal has been beneficial to the U.S. government postal operator.
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The Day 1 Academies Fund will launch and operate a network of high-quality, full-scholarship, Montessori-inspired pre-schools in low-income and underserved communities, he said.
"But it is really risky to demonise the media. In the caption, he wrote, "September is Childhood Cancer Awareness month", he further wrote that Amazon employees around the globe will be wearing pjs to work to show their solidarity and support to children suffering from the deadly disease". We're going to be obsessively, compulsively focused on the child.
Mr. Trump has described the Washington Post as Amazons chief lobbyist. The child will be the customer.
Since then, he and his wife have built the Bill & Melinda Gates Foundation, which had an endowment of US$51 billion at the end of 2017 and pledges to spend all its resources within 20 years of its founders' deaths. Neither was aware of any information beyond what was disclosed by Bezos, and both said their organisations had not been asked to advise the use of the Day 1 funds.