"Maybe some players will stay here to try to reach the level, to give more time, for different reasons - because maybe we don't want to take risks, because they need more preparation, because the background or history of their injuries is different".
Pogba has at times endured a hard relationship with United boss Mourinho.
Sergio Romero, Valencia, Marcos Rojo, Dalot, Ander Herrera and Matic are all injured for Leicester's visit, while Mourinho needs to check on the fitness of those that returned late from the World Cup.
The former England midfielder pointed to a gulf in class - and playing styles - with Pep Guardiola's free-flowing Manchester City, who won the title 19 points ahead of their neighbours last season.
"The players with a proper pre-season are fit and they are strong.
We believe a lot in our players and there's no point now to say, why not repeat a similar season like past year or the season before, and with more experience".
"Newcastle of course in this period have an advantage to us in their preparation with the whole squad, but that is not a reason to complain".
"So I will have to focus on the players I have".
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"In pre-season it looked like I was saying something absolutely out of order, it looked like I was saying something insane", he added.
"I am happy to keep all the squad together".
"This target seems unrealistic but if every fan donates just a pound we can help get back to attacking winning ways".
The ingredients appear to be in place for another Mourinho meltdown should United get off to a bad start and he believes even the scheduling of his side's opening fixture has made his task even harder.
"You don't really know the team, you don't really know the players, you don't know how they're going to perform from one week to the next".
"Their team is definitely already good enough to challenge champions Manchester City for the title, but can Jose get the best out them?"
"My view is that, first of all, is hard for me to believe we finished second", he said.
Top flight sides had previously voted to close the window before their season began, meaning that they would have to complete all deals by August 9.