The studies will involve transplanting nerve cells produced by human iPS cells into the brains of Parkinson's disease patients, and will be conducted by a team led by Jun Takahashi, a professor of neurosurgery at the university's Center for iPS Cell Research and Application (CiRA).
The same technology is also the basis for this novel Parkinson's disease treatment, which aims to convert millions of iPS cells into so-called dopaminergic progenitors - neurons that can generate the dopamine neurotransmitter in the brain and replenish the low dopamine levels responsible for the onset of Parkinson's symptoms.
Parkinson's disease, a chronic, degenerative neurological disorder, affects the body's motor system, causing people to shake and have difficulty with movements.
Now available therapies "improve symptoms without slowing or halting the disease progression", the foundation says. This clinical test will begin on Wednesday. No tumors has been identified that could develop cancer brain over two years of observations. According to the results, the animals experienced significant improvement after receiving injections with human iPS cells - thereby propelling the treatment into human trials.
Last year, Takahashi and his colleagues reported that the injected cells could survive in monkey brains for up to two years, and that the treatment improved symptoms in a primate model of Parkinson's disease.
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"Our research has shown that DA neurons made from iPS cells are just as good as DA neurons made from fetal midbrain", he said previous year in a press release.
The team will create about 5 million dopamine-producing neurons using iPS cells from other people that the research center has preserved.
These can be derived from the patient, making them less likely to be rejected, while also sidestepping ethical qualms about taking cells from embryos.
Researchers at Osaka University will start clinical studies soon to treat heart failure using sheets of cardiac muscle cells created from iPS cells.
With other tests of the IPS cells, the world's first transplant of retinal cells developed from iPS cells to a patient experiencing a genuine ailment in 2014, made by the government Riken.
In the USA, scientists from Duke University said in January they had managed for the first time to grow functioning human muscle from iPS cells in the lab.