While the Federer exit, to South African Kevin Anderson, losing 13-11 in the final set, is what will sadden most viewers and grab what there are of tennis headlines today, Nadal coming from two sets to one down against perennial almost man Juan Martin Del Potro produced perhaps the most awesome tennis of the day, and definitely the moment of the tournament.
But while Nadal and three-time champion Djokovic were expected to win, and Isner seeded to do so over Raonic, Anderson had never even extracted a set from Federer in four previous meetings. But [Djokovic] is playing good again. "I have to come to the net very often and play hard with my forehands, with my backhands, and try to take all the chances".
Incidently, the Nadal versus Del Potro match lasted exactly the same length as Rafa's win against Roger Federer in the 2008 final.
Anderson's experience of having already won a grand slam semi-final may also be a factor here.
Nadal, 32, and Djokovic, 31, meet in a highly anticipated Wimbledon semi-final at about 16:30 BST on Friday.
The mental strength, arguably the characteristic that propelled him to world No 1 for the first time in 2011 and kept him at the top of the game for five years is back.
Spain's Nadal and Serbia's Djokovic have won 29 Grand Slam titles between them, including five previous victories at SW19.
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Nadal was two sets to one down before fighting back to win in five sets - and nearly five hours - to reach his first SW19 semi-final since 2011.
Second, his opponent will be two-time Wimbledon champion Rafael Nadal. "In some ways he deserves to go through too", Nadal told the BBC after the match.
The more gusty conditions on No. 1 Court could make Federer's challenge against eighth-seeded Kevin Anderson more complicated.
"I'm like, "You don't have to be sorry".
"My results were not up to the standard that I had before", said Djokovic after beating Kei Nishikori in the quarter-finals.
Isner, 33, will be playing in his first major semi-final and is bidding to become the first American man to reach a Slam final since Andy Roddick finished Wimbledon runner-up in 2009.