The explosion could be heard from Heliopolis to Rehab areas in Cairo.
The explosion reportedly took place just before 11 p.m. local time. Sky News Arabic correspondent Faisal bin Huraiz shared an eyewitness video showing an explosion in the direction of what appeared to be Cairo International Airport.
He said air movement at the airport had been "unaffected".
Reuters has reported that all activity at the airport has been suspended, but some locals report that operations have either been resumed or were never stopped in the first place.
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Egyptian state television is reporting that a fire raging as a result of the explosion had been brought under control.
The ministry's spokesperson affirmed that the flights at the airport were not at all affected by the explosion. In February 2015 authorities discovered bombs planted at the Cairo International Airport on the same day that a blast killed a man in Egypt's second city of Alexandria.
Though there isn't any official information yet, some speculate that the explosion could somehow be connected to clashes between ISIS and Egyptian security forces in the region.
This is a breaking story.