Lopetegui, who has been in charge of the national team for the past two years, has agreed a three-year contract at the Bernabeu. Lopetegui is now in Russian Federation preparing the Spanish squad for the World Cup.
"So I think everybody will be happy with it, but mostly because Real were surprised by the departure of Zidane and had to react as soon as possible".
However, Real finished third in La Liga in the season just finished, 17 points behind champions Barcelona, and Zidane had admitted that he was unsure of his ability to oversee more success in the future.
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And United supporters are concerned that new Madrid boss Lopetegui will use Spain's World Cup campaign as a chance to lure De Gea away from Old Trafford.
The Spanish giants broke the news in a Tweet on Tuesday.
He has agreed a three-year deal with the European champions and will officially take charge after the World Cup in Russian Federation.
The France legend subsequently took the decision to step down, and a replacement has now been found, though expectations are unlikely to be any lower.
Whatever did happen, the timing is unfortunate for La Roja as they aim for World Cup glory and also for Los Blancos in their building for the 2018-19 season, while question marks over the coach's suitability for such a top job also persist.