While Fury showboated his way through the contest against an opponent whom he out-weighed by four and a half stone and towered over by a foot, the only real aggression was shown by fans engaging in a mid-bout brawl outside the ring.
Fury has been linked with a clash against former WBC cruiserweight champion Tony Bellew, who is roughly the same size as Seferi.
Fury back in action on Saturday night after more than two years out of the ring won after his hopelessly inadequate opponent quit on his stool - will now head for Belfast for his next outing.
Fury extended his unbeaten record to 26 wins, 19 by knockout, while Seferi suffered his second defeat in 25 fights.
Promoter Frank Warren said they are still trying to work weight off Fury, and ring rust.
One thing is for sure, boxing fans loved it.
Seferi is 39, has not boxed at an elite level, was 7 inches smaller and almost 70 pounds lighter than Fury.
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"We took Seferi, who had a good record and a tough chin and he took me a few rounds".
"I wanted to see Tyson get some more rounds".
He vowed: "I'm happy to to be back and I'll take my career very seriously this time".
It was always comfortable for Fury in his first fight since winning the World Boxing Association (WBA), International Boxing Federation (IBF) and World Boxing Organisation (WBO) titles from Ukraine's Wladimir Klitschko on points in November 2015.
Joshua and Wilder are in talks to face each other in early 2019, while Warren plans on keeping Fury active until a world title shot happens, with his next bout scheduled to be at Belfast´s Windsor Park, Northern Ireland on August 18. I won't take anything for granted and I'll enjoy every moment.
However, Fury began to knuckle down in rounds three and four, landing right hands seemingly at will, although Seferi appeared to be taking the blows well.
After ending Klitshcko's near-decade-long reign of the heavyweight division, Fury received his boxing licence in January after accepting a backdated two-year doping ban.