Maduro routinely accuses the United States of seeking to overthrow his government and says that Venezuela's extreme economic problems - with a drastic contraction in economic production and the world's highest inflation - are the result of an "economic war" being waged against the country by Washington.
The actions Friday by the Treasury Department freezing any US assets Cabello has and preventing Americans from doing business with him comes as tensions mount between Washington and Venezuela ahead of Sunday's presidential election, which the Trump administration refuses to recognize.
The latest sanctions come just two days before the country holds an election that Maduro is nearly certain to win. Proceeds from those drug deals were divided with others including Maduro, Treasury said.
There was no immediate reaction from the government or Cabello.
The sanctions order also designates three companies - 11420 Corp, Noor Plantation Investments LLC and SAI Advisors Inc, described in a Treasury statement as Florida companies owned or controlled by Sarria - according to the Treasury Department website.
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On Friday morning, the hospital confirmed that Mr Skripal had left the hospital, following his daughter's discharge on April 10. But the Russian government denied any involvement and has accused the United Kingdom of inventing a "fake story".
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The government has also told the current attorney general, who cleared Najib of wrongdoing in 2016, to go on leave. Asked to comment, Najib, 64, patted an AFP journalists' arm and said: "Later, later".
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Venezuela is suffering major food shortages and has refused foreign food packages offered by neighboring countries and the United States.
"The Venezuelan people suffer under corrupt politicians who tighten their grip on power while lining their own pockets", Treasury Secretary Steven Mnuchin said in a statement".
The U.S. Treasury accused Cabello, a former president of the country's national assembly, of money laundering and direct involvement in trafficking narcotics from Venezuela through the Dominican Republican to Europe.
Republican Marco Rubio and Democrat Robert Menendez in January called on the Justice Department to investigate allegations of drug trafficking by senior officials in Maduro's government.