Speaking to PBS NewsHour, US State Department official Brian Hook claimed signatories to the Joint Comprehensive Plan of Action (JCPoA) - also known as the Iran deal - have to start making their own decisions following criticism against Donald Trump's announcement to pull the US out of the agreement.
After China, the Iranian foreign minister was scheduled to fly to Moscow for talks with his Russian counterpart Sergei Lavrov and then Brussels to consult with British, French and German foreign ministers as well as European Union foreign policy chief Federica Mogherini.
But analysts said Iran was determined to maintain the moral high ground in the coming weeks.
The other signees had urged Washington to remain in the deal.
"We have always been at one with the U.S. in our profound concern over Iran's missile tests and the disruptive role in the Middle East, particularly in Yemen and Syria".
It called on the other parties to the agreement - especially Britain, France and Germany - to safeguard the accord, adding that no provisions or time frames in the 2015 agreement "are negotiable in any manner". The announcement triggered US plans to reimpose sanctions on the Islamic Republic within roughly three to six months.
The nuclear deal imposed restrictions on the Islamic Republic's nuclear program in return for the lifting of most of the USA and global sanctions against Tehran.
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Iran says as far as it's concerned the United States pullout has not killed the nuclear deal.
Khamenei said this week he is highly doubtful that Europe will provide the "real guarantees" needed for Iran to stay in the nuclear deal.
"Do we want to be vassals who obey decisions taken by the United States while clinging to the hem of their pants?" Le Maire asked. "Or do we want to say we have our economic interests, we consider we will continue to do trade with Iran?".
"This deal is not a bilateral treaty".
"They agreed on the need for calm on all sides and on the importance of tackling Iran's destabilizing activity in the region", the spokeswoman said.
On Saturday evening French President Emmanuel Macron phoned Trump to "take stock of trade issues and discuss the situation in the Near and Middle East", the Elysee said in a statement. It was widely believed to have been a successful piece of global diplomacy at the time, but Trump repeatedly referred to the deal as being the "worst ever" during his election rallies, pointing out that it made no mention of the Iranian ballistic program or the overall influence Iran exerted in the Middle East.