A record 28th Bundesliga crown was secured last weekend with a 4-1 win at derby rivals Augsburg, Heynckes' fourth as Bayern boss, and they now sit 20 points clear at the top of the table.
Cristiano Ronaldo's reigning champions bring three away goals home from Turin, and it's hard to believe even a club as storied as Juve can collect a three-goal win given the opposition and the venue of the Bernabeu.
On Wednesday night, we'll find out who will join Roma and Liverpool in the semi-finals - and there are clear favourites in both the ties.
Sevilla, though, have won just two of their last 14 away games in the competition (not including qualifiers) and Vincenzo Montella's side are priced at 14/1 (15.00), with the draw at 6/1 (7.00). Ahead of the second leg meeting on Wednesday, The Hard Tackle takes a closer look at the encounter.
Billed as a meeting of two European heavyweights, this blockbuster quarter-final proved a one-sided affair with a Real Madrid side inspired by Cristiano Ronaldo scoring three times without reply in Turin.
His second goal was an audacious overhead kick which dampened the spirits of Juventus and captured all the headlines.
The visitors would have to do without talisman Paulo Dybala, who was red-carded in the first leg and is out suspended for this encounter.
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Madrid have now failed to beat Atletico in their last five league games at the Bernabeu (two draws, three defeats). What we have done in this decade is tremendous, Atletico fans should be proud of how their team is competing.
Arjen Robben said Bayern Munich can take nothing for granted against Sevilla in their Champions League quarter-final, second leg as the Spanish side had dumped Manchester United out of the competition.
Pablo Sarabia had put Sevilla last week, only for Bayern to quickly draw level thanks to a Jesus Navas own goal before Thiago Alcantara headed home their second-half victor. Zinedine Zidane's men know exactly what they need to do in order to ensure passage to the next round and would be ready to put in a professional performance at home.
Sevilla, have the chance of rewriting history, as they have never reached the semi-finals of the Champions League.
If Sevilla are going to advance to the semifinals, they are going to have to do what no team has done this season, beat Bayern inside the Allianz Arena.
Bayern's detractors will point to their recent Champions League record.
The possible Sevilla and Bayern Munich line-ups and formations.